Apr 22, 20 the calcifying odontogenic cyst gorlin cyst. Current concepts and occurrence of epithelial odontogenic. Like other odontogenic neoplasms, it is thought to arise from the epithelial element of the enamel origin. The calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by gorlin. Clear cell variant of calcifying epithelial odontogenic tumor. Occlusal technique projection of a calcifying epithelial odontogenic cyst showing expansion of the buccal cortical plate. The calcifying odontogenic cyst gorlin cyst pure facts. The intention was to redefine these lesions as cystic neoplasms, but the evidence for doing so was not clear and was controversial. Calcifying odontogenic cyst synonyms, calcifying odontogenic. The lesion was surgically removed by enucleation and. Also called as odontogenic ghost cell cyst or gorlin cyst. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development.
It accounts for less than 1% of all odontogenic tumors. Developmental inflammatory odontogenic keratocyst radicular dentigerous cyst residual eruption cyst paradental gingival cyst of infants gingival cyst of adults lateral periodontal cyst calcifying odontogenic. Kramer 1974 has defined a cyst as a pathological cavity having fluid, semifluid or gaseous contents and which is not created by the accumulation of pus. Synonyms for calcifying odontogenic cyst in free thesaurus. Calcifying odontogenic cyst with luminal and mural. Cystic variant of calcifying epithelial odontogenic tumor. Gorlin and coworkers 1962 lesion unusual some features of a cyst and also of a solid neoplasm. The ductlike, tubular, or cordlike areas are lined by cuboidal to columnar epithelial cells fig. Calcifying odontogenic cyst with odontogenic keratocyst oral surg oral med oral pathol oral radiol endod 2010. It strikes distinct age groups, with an average patient age being 50 years. Aot from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts, and amelobastomas is sometimes difficult.
Odontogenic cysts that can be problematic because of recurrence andor aggressive growth include odontogenic keratocyst okc, calcifying odontogenic cyst, and. Adenomatoid odontogenic tumor aot mixed calcifying epithelial odontogenic tumor ceot calcifying odontogenic cyst gorlin cyst odontoma mixed lesion cementoblastoma. Calcifying odontogenic cyst synonyms, calcifying odontogenic cyst pronunciation, calcifying odontogenic cyst translation, english dictionary definition of calcifying odontogenic cyst. Synchronization of calcifying odontogenic cyst and aneurysmal. Calcifying epithelial odontogenic cyst of the mandible figueiredo. Odontogenic cysts, tumors, and related jaw lesions preceptor. In onethird of cases, an impacted tooth is involved. The calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by gorlin in 1962. Pdf calcifying epithelial odontogenic cyst in maxilla. Glandular odontogenic cyst of maxilla journal of clinical. Calcifying epithelial odontogenic tumor an overview. Two of three calcifying epithelial odontogenic tumors and five of five gocs were also positive. Calcifying cystic odontogenic tumor in a 5yearold boy. The calcifying epithelial odontogenic tumor is a rare benign odontogenic neoplasm of the jaw.
The origin of this tumor is controversial, and it is believed that it can be derived from oral epithelium, reduced enamel epithelium, intermediate stratum or even dental lamina remnants 1, 2. The calcifying odontogenic cyst coc is a simple cyst lined by ameloblastomalike epithelium with ghost cells. Ameloblastoma, calcifying epithelial odontogenic tumor, and. It has morphological similarities to other lesions, which makes its diagnosis challenging for pathologists. Calretinin is a calciumbinding protein that has been suggested to. Histologically, nodules of odontogenic epithelium are separated by minimal stromal connective tissue. Intrabony cysts are most common in the jaws, because the mandible and maxilla are the only bones with epithelial. Pdf calcifying cystic odontogenic tumour mimicking as a. A the epithelial lining of the calcifying cystic odontogenic tumor displays palisading of the basal layer, proliferation of epithelial cells towards the cyst lumen and ghost cells in the cystic epithelium.
In general, epithelium within an intraosseous, gnathic location may have a broad differential diagnosis depending on the amount of epithelium present for evaluation, type of epithelium, anatomic location of lesion in gnathic bones, radiographic. Jul 24, 2010 the world health organization classification of head and neck tumors classifies the lesion as an odontogenic tumor and names it calcifying cystic odontogenic tumor. In the formation of a cyst, the epithelial cells first proliferate and later undergo degeneration and liquefaction. The world health organization classification of head and neck tumors classifies the lesion as an odontogenic tumor and names it calcifying cystic odontogenic tumor. Lateral periodontal cyst glandular odontogenic cyst unclassified paradental cyst calcifying odontogenic cyst 9. Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression.
Extraosseous or peripheral lesions account for less than 5% of cases. C numerous calcified particles and d ghost cells are present adjacent to the epithelial lining of coc. It may also arise from the epithelial lining of these cysts. The paper reports on two new cases of calcifying odontogenic cysts, and gives a survey of 50 cases reported in the literature. The term calcifying odontogenic cyst was first introduced by gorlin in 1962 eshghyar et al. Calcifying odontogenic cyst is a rare and specific lesion with properties of a tumor that can appear anywhere on the body and have properties of a cyst. Calcifying epithelial odontogenic tumor of the maxilla. The calcifying odontogenic cyst coc 1 is a cystic lesion lined by an ameloblastomalike epithelium containing ghost cells and calcifications. Who defined it as a cystic lesion in which the epithelial lining shows a welldefined basal layer of columnar cells, an overlying layer that is often many cells thick and that may resemble. Different manifestations of calcifying cystic odontogenic tumor. Calcifying epithelial odontogenic tumor ceot is a rare, benign, locally aggressive odontogenic epithelial tumor that affects the jaws.
The calcifying odontogenic cyst or gorlin cyst was originally identified as an independent condition by gorlin in 1962 year. Pdf calcifying odontogenic cyst or gorlin cyst, was first described by gorlin. The calcifying cystic odontogenic tumor ccot, formerly known as calcifying odontogenic cyst, is a rare developmental neoplasm cyst of odontogenic epithelial origin with considerable histopathologic diversity and variable clinical behaviour. Calcifying epithelial odontogenic cyst, also known as gorlin cyst, showing radiographic evidence of calcified material in the radiolucency. Show full abstract present a case of calcifying epithelial odontogenic cyst in maxillary anterior region, in a 25yearold female patient. Different manifestations of calcifying cystic odontogenic. We briefly discuss the radiologic features of calcifying epithelial odontogenic tumor and the relevant literature.
With this we made a final diagnosis of calcifying ghost cell odontogenic cyst. Calcifying cystic odontogenic tumor ccot is an uncommon odontogenic tumor. This article is from korean journal of pathology, volume 48. Calcifying odontogenic cyst dentinogenic ghost cell tumour ghost cell odontogenic carcinoma 14. On radiographs, the calcifying odontogenic cyst appears as a unilocular radiolucency dark area. Histologically, ccot is usually composed of a cystic cavity with fibrotic capsule lined by an odontogenic epithelium. Calcifying epithelial odontogenic cyst associated with. Ct and mr imaging appearances of an extraosseous calcifying. This is a temporary file and hence do not link it from a website, instead link the url of this page if you wish to link the pdf file.
It is defined as a cystic lesion in which the epithelial lining shows a well defined basal layer of columnar cells, an overlying layer that often resemble stellate reticulum and masses of ghost cells that may be in the epithelial cystic lining or in the fibrous capsule. Pdf the calcifying epithelial odontogenic cyst ceoc is a developmental. Calcifying odontogenic cyst definition of calcifying. The center of the ball of cells then has a higher protein. Aug 31, 20 the calcifying cystic odontogenic tumor ccot, formerly known as calcifying odontogenic cyst, is a rare developmental neoplasm cyst of odontogenic epithelial origin with considerable histopathologic diversity and variable clinical behaviour. A dentigerous cyst results because of the enlargement of the follicular space of the whole or part of the crown of an impacted or. Odontogenic cysts, odontogenic tumors, fibroosseous, and. A report of an extraosseous calcifying odontogenic cyst ecoc in a 57yearold black woman is. The calcifying epithelial odontogenic tumor ceot was described in 1955 by jens jorgen pindborg, a dutch pathologist 1, 2. The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al.
Dystrophic calcification and respiratory metaplasia in the. Calcifying epithelial odontogenic tumor ceot is a rare benign, but locally infiltrating odontogenic neoplasm. Areas of an eosinophilic matrix material compatible dentinoid also may present adjacent to the epithelial component. Calponin reactivity was at least focally present in two of four calcifying epithelial odontogenic tumors, three of five gocs, and 10 of 11 ameloblastomas. Calcifying odontogenic cyst gorlin cyst ddmfr oral and. Orthokeratinized odontogenic cyst should be considered in the differential. Unicystic ameloblastoma arises from similar tissues as the odontogenic cysts.
One case of calcifying epithelial odontogenic tumor was focally positive for glial fibrillary acidic protein. It was previously described as an adenoid adamantoblastoma, unusual ameloblastoma and a cystic odontoma. Calcifying ghost cell odontogenic cyst is comparatively rare in occurrence, constituting about 0. Surgical management of a large calcifying epithelial. The cyst may sometimes be associated with benign odontogenic tumors. Calcifying epithelial odontogenic cyst a case report. We herein report a rare case of extraosseous calcifying epithelial odontogenic tumor with local aggressive behavior.
Although rare, because of its variable presentation calcifying cystic odontogenic tumor should be included in the differential diagnosis of jaw lesions. The calcifying epithelial odontogenic tumor ceot, also known as a pindborg tumor, is an odontogenic tumor first recognized by the danish pathologist jens jorgen pindborg in 1955. Odontogenic epithelium an overview sciencedirect topics. This cyst is part of a spectrum of lesions characterized by odontogenic epithelium containing ghost cells, which may undergo calcification. A calcifying epithelial odontogenic tumor ceot is a locally invasive epithelial neoplasm characterized by the development of intraepithelial structures, probably of an amyloidlike nature, which may become calcified and liberated as the cells break down. Clinically, calcifying epithelial odontogenic tumor manifests as an intraosseous lesion central type in the majority of cases 95%.
Some of the ghost cells appear to undergo dystrophic calcification figure 5. Calretinin expression in unicystic ameloblastoma and. It is most common in people in their second to third decades but can be seen at almost any age. Calcifying odontogenic cyst coc was first described and classified by gorlin et al. Pdf calcifying epithelial odontogenic cyst a case report. Although there are numerous reports on the variants of ceot, occurrence of clear cells with complete absence of calcification has been a rarity. Odontogenic cysts are defined as epithelial lined structures derived from odontogenic.
Furthermore, the epithelial lining of unicystic ameloblastoma is variable and may be almost completely nondescript, which may lead to diagnostic confusion with odontogenic cysts. These findings are not specific and simulate an ameloblastoma, dentigerous cyst, or other odontogenic tumors. Calcifying epithelial odontogenic pindborg tumor in a child. These cells are loosely arranged and show a peripheral basal cell layer that has a cuboidal or columnar appearance, microscopic features similar to. Calcifying odontogenic cyst, odontogenic tumors, epithelium, ectomesenchyme ghost cell, enucleation, unerupted teeth. Calcifying odontogenic cyst or gorlin cyst, was first described by gorlin. Calcifying odontogenic cysts, a type of developmental odontogenic cyst, present in intraosseous and extraosseous forms. It appears as a cyst lined by an ameloblastic epithelium, containing variable amounts of ghost cells and calcifications. It is an unusual and unique lesion, which may show characteristics of both a solid neoplasm and a cyst.
Most of the cells were anuclear or contained pyknotic nuclei. The calcifying odontogenic cyst is an uncommon odontogenic lesion that can have intra or extraosseous occurrence with both cystic or tumor behavior. The calcifying cystic odontogenic tumor normally presents as a. The cystic lining epithelium was composed of calcifying, keratinizing, squamous, and columnar epithelial cells, and included calcified masses of irregular shape. Abstract calcifying epithelial odontogenic tumors ceots and ghost cell odontogenic tumors gcots are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. Mcqs on odontogenic cysts and tumors oral pathology. A calcifying cystic odontogenic tumor ccot is a proliferation of. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium.
Pdf ameloblastoma, calcifying epithelial odontogenic. The epithelial lining was 34 cells thickness exhibiting globules of eosinophilic structure suggestive of ghost cells figures figures3 3 and and4. Glandular odontogenic cyst goc is a rare developmental lesion that is considered a distinct entity because of its uncommon histopathological characteristics. Calcifying odontogenic cyst with extensive areas of dentinoid. Calcifying odontogenic cyst was first described by gorlin et al. Calcifying odontogenic cyst immunohistochemical detection of. Dentigerous cyst odontogenic keratocyst orthokeratinized odontogenic cyst gingival alveolar cyst of the newborn gingival cyst of the adult lateral periodontal cyst calcifying odontogenic gorlin cyst glandular odontogenic cyst eruption cyst cyst lumen lining epithelium. The occurrence of ccot in the first decade of life is very uncommon. Pdf calcifying epithelial odontogenic cyst of the mandible. Etiology and pathogenesis derived from odontogenic epithelial remnants within the gingiva or within the mandible or maxilla.
Different manifestations of calcifying cystic 367 einstein. Cysts grow by expansion and thus displace the adjacent teeth by pressure. The calcifying epithelial odontogenic tumor ceot is a rare benign epithelial odontogenic neoplasm of slow growth that is locally aggressive and tends to invade bone and adjacent soft tissue. Calcifying epithelial odontogenic cyst epithelium tissue. Calcifying cystic odontogenic tumor accompanied by a dentigerous. Aug, 2015 calcifying odontogenic cysts and odontomas 1. In most instances, the calcifying odontogenic cyst is composed of a fibrous capsule that is lined with a proliferation of odontogenic epithelial cells fig. A cyst is defined as pathological cavity lined by epithelium filled with fluid, semifluid or gaseous contents. Jun 07, 20 a cyst is an epitheliumlined sac containing fluid or semisolid material. The calcifying epithelial odontogenic cyst is an uncommon benign lesion. The odontogenic cysts are a diverse groups of odontogenic lesions of the jaws the radicular cyst is an inflammatory lesion, and although by far the most common, it is clinically easy to diagnose and manage other cysts are less frequently encountered and some e. Odontogenic cysts are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. The calcifying cystic odontogenic tumor can occur in any location of the oral cavity and approximately 6567.
In general, epithelium within an intraosseous, gnathic location may have a broad differential diagnosis depending on the amount of epithelium present for evaluation, type of epithelium, anatomic location of lesion in gnathic bones, radiographic appearance, clinical scenario and patient demographics. Here is reported the case of a 21yearold female patient with a ceot in the left mandibular posterior region. Chronic osteomyelitis mixed florid cementoosseous dysplasia mixed fibrous dysplasia mixed cementoossifying fibroma 2nd stage paget disease. The lesion is unusual in that it has some features of a cyst but also has many characteristics of a solid neoplasm cysts and tumors of odontogenic origin. According to the who classification of jaw cysts, dc is defined as an epithelial developmental odontogenic cyst 8. Who classification system 3 categories based on cystic, solid or malignant nature of the lesion. Adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor extrafollicular adenomatoid odontogenic tumor mimicking residual cyst adenomatoid odontogenic tumor. A cyst is an epitheliumlined sac containing fluid or semisolid material. The following classification system is a modification of the world health organization.
Ameloblastoma, calcifying epithelial odontogenic tumor. Calcifying cystic odontogenic tumor accompanied by a. Dc is defined as an epithelial developmental odontogenic cyst 8. An abnormal membranous sac in the body containing a gaseous, liquid, or semisolid substance.
The liquefied material exerts equal pressure on the walls of the cyst from within. The calcifying ghost cell odontogenic tumor or the. In approximately 52% of the cases, the tumor is associated with impacted teeth and is twice as prevalent in the mandible than the maxilla. The peripheral coc is a rare lesion and few reports have been published considering its clinical and histopatholo. The origin of this tumor is controversial, and it is believed that it can be derived from oral epithelium, reduced enamel epithelium, intermediate stratum or. Calcifying odontogenic cyst is a wellcircumscribed, solid, or cystic lesion derived from odontogenic epithelium which develops from reduced enamel epithelium. Calcifying cystic odontogenic tumour mimicking as a residual cyst.
Calcifying epithelial odontogenic cyst of the mandible. Has many features of odontogenic tumor, therefore it is placed in the category of tumors in the latest who classification of odontogenic cysts and tumors. Calcifying odotogenic cyst is a benign odontogenic tumor of cystic type most likely to affect the anterior areas of the jaws. Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by. Ct and mr imaging showed the distinctive appearances of this histologic entity.
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